HomeMCPWorkbenchSkills
HomeWorkbenchNotificationsMe
llms.txt · MCP GuidePrivacy Policy · Terms of Service · Supportv1.8.0
  1. Home
  2. /Reaction

(S)-2-phenyl-3-tert-butyl-5-hydroxymethyloxazolidine → 2-(3-tert. Butylamino-2-acetoxypropoxy)-3-cyanopyridine

HRID 1111856
Notes
Print preview

Reaction equation

HRID 1111856 reaction equation
C1(C2[N:11](C(C)C)[CH2:10]C(CO)O2)C=CC=CC=1.C[C@H]1N(C(CC)C)CC(CO)[O:19]1.[CH:29]([N:32]1[CH2:36][CH:35]([CH2:37]O)OC1)([CH3:31])C.[C:39]1([C@H:45]2[N:49]([C:50]([CH3:53])([CH3:52])[CH3:51])[CH2:48][CH:47]([CH2:54][OH:55])[O:46]2)C=CC=CC=1>>[C:50]([NH:49][CH2:48][CH:47]([O:46][C:45](=[O:19])[CH3:39])[CH2:54][O:55][C:36]1[C:35]([C:10]#[N:11])=[CH:37][CH:31]=[CH:29][N:32]=1)([CH3:51])([CH3:52])[CH3:53]
ParticipantsProcedureSources & evidenceReaction notes

Participants

5

Reactant 4

HCID 12296652(S)-2-phenyl-3-tert-butyl-5-hydroxymethyloxazolidineHCID 125661982-Phenyl-3-isopropyl-5-hydroxymethyloxazolidineHCID 213212873-Isopropyl-5-hydroxymethyloxazolidineHCID 131710938(S)-2-methyl-3-sec. butyl-5-hydroxymethyloxazolidine

Product 1

HCID 1317109372-(3-tert. Butylamino-2-acetoxypropoxy)-3-cyanopyridine

Procedure

Isopropyl or sec. butyl amino analogues of the compounds of the above examples are prepared by substituting suitable oxazolidines e.g. 2-phenyl-3-isopropyl-5-hydroxymethyloxazolidine, (S)-2-methyl-3-sec. butyl-5-hydroxymethyloxazolidine, 3-isopropyl-5-hydroxymethyloxazolidine for the (S)-2-phenyl-3-tert. butyl-5-hydroxymethyloxazolidine reactant.

Sources & evidence

ORD record
ord-eb8c46b6bb6e487698fb2a09a8b7aba3
Source dataset
uspto-grants-1978_10
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US04119630

Reaction notes

Loading…

On this pageParticipantsProcedureSources & evidenceReaction notes