Sodium Carbonate → S-[2-(5-Methyl-4-imidazolylmethylthio)ethyl]-N-cyano-N'-methylisothiourea
Reaction equation
Cl.[CH3:2][C:3]1[NH:7][CH:6]=[N:5][C:4]=1[CH2:8][S:9][CH2:10][CH2:11][S:12][C:13](=[N:17][CH3:18])[NH:14][C:15]#[N:16].C(=O)([O-])[O-].[Na+].[Na+]>>[CH3:2][C:3]1[NH:7][CH:6]=[N:5][C:4]=1[CH2:8][S:9][CH2:10][CH2:11][S:12][C:13](=[N:17][CH3:18])[NH:14][C:15]#[N:16]Participants
3
Procedure
This hydrochloride may be treated with aqueous sodium carbonate and the mixture extracted with chloroform and the chloroform extracts evaporated to give the free base.
Workup
- extractionthe mixture extracted with chloroform
- customthe chloroform extracts evaporated
- customto give the free base
Sources & evidence
- ORD record
- ord-2e686f1ded1448ffbdd7d3f2d5849250
- Source dataset
- uspto-grants-1978_10
- Patent number
- US04120966
Reaction notes
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