Sulfuric Acid → 1-Amino-3,5-dimethyl-adamantane sulfate

HRID 1112397

Reaction equation

HRID 1112397 reaction equation
[NH2:1][C:2]12[CH2:11][C:6]3([CH3:12])[CH2:7][CH:8]([CH2:10][C:4]([CH3:13])([CH2:5]3)[CH2:3]1)[CH2:9]2.[S:14](=[O:18])(=[O:17])([OH:16])[OH:15]>CCOCC>[S:14]([OH:18])([OH:17])(=[O:16])=[O:15].[NH2:1][C:2]12[CH2:3][C:4]3([CH3:13])[CH2:10][CH:8]([CH2:7][C:6]([CH3:12])([CH2:5]3)[CH2:11]1)[CH2:9]2

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 4054Memantine

Product 1

HCID 706289471-Amino-3,5-dimethyl-adamantane sulfate

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The dried ether solution of 1-amino-3,5-dimethyl-adamantane was treated with 0.5 gram concentrated sulfuric acid (H2SO4) in an ice bath, shaken, and the ether distilled. The oily residue was crystallized from hot water. Yield: 1.81 grams (80% of the theoretical yield).

Workup

  1. distillationthe ether distilled
  2. customThe oily residue was crystallized from hot water
  3. customYield: 1.81 grams (80% of the theoretical yield)

Sources & evidence

ORD record
ord-bd8d4e4829a2408b996d7970f31f0b41
Source dataset
uspto-grants-1978_10
Patent number
US04122193

Linked notes

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