4-((3,5-Bis(trifluoromethyl)benzyloxy)methyl)-4-phenylazepane → HCID 21973113, compound

HRID 11221

Reaction equation

HRID 11221 reaction equation
FC(F)(F)C1C=C(C=C(C(F)(F)F)C=1)COCC[C:10]1([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:16][CH2:15][CH2:14][N:13]([CH2:17][CH3:18])[CH2:12][CH2:11]1.[F:34][C:35]([F:63])([F:62])[C:36]1[CH:37]=[C:38]([CH:55]=[C:56]([C:58]([F:61])([F:60])[F:59])[CH:57]=1)[CH2:39][O:40][CH2:41]C1(C2C=CC=CC=2)CCCNCC1>>[F:34][C:35]([F:62])([F:63])[C:36]1[CH:37]=[C:38]([CH:55]=[C:56]([C:58]([F:61])([F:60])[F:59])[CH:57]=1)[CH2:39][O:40][CH2:41][C:10]1([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:16][CH2:15][CH2:14][N:13]([CH2:17][CH3:18])[CH2:12][CH2:11]1

Participants

3

Reactant 2

HCID 116261604-((3,5-Bis(trifluoromethyl)benzyloxy)methyl)-4-phenylazepaneHCID 86602717HCID 86602717, compound

Product 1

HCID 21973113HCID 21973113, compoundYield 62%

Procedure

Isomer B of 4-((3,5-bis(trifluoromethyl)benzyloxy)ethyl)-1-ethyl-4-phenylazepane was made from Isomer B of 4-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-4-phenylazepane in the same manner as described above to give the product as a clear sticky oil (2 mg, 62% yield).

Sources & evidence

ORD record
ord-063a518b9b59485c8f6e95e9593b3357
Source dataset
uspto-grants-2006_08
Patent number
US07098203B2

Linked notes

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