1-Chloro-4-(chloromethyl)benzene → 2-(4-chlorobenzyl)-6-(3-fluoro-4-methoxyphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one

HRID 112372

Reaction equation

HRID 112372 reaction equation
[Cl:42][c:43]1[cH:44][cH:45][c:46]([CH2:47][Cl:48])[cH:49][cH:50]1.[F:1][c:2]1[cH:3][c:4]([F:5])[cH:6][cH:7][c:8]1-[c:9]1[cH:10][c:11]([CH2:12][OH:13])[c:14](=[O:15])[n:16]([CH2:17][CH:18]([CH3:19])[CH3:20])[n:21]1.[F:22][c:23]1[cH:24][c:25](-[c:31]2[cH:32][c:33]([C:38](=[O:39])[O:40][CH3:41])[c:34](=[O:37])[nH:35][n:36]2)[cH:26][cH:27][c:28]1[O:29][CH3:30]>>[F:22][c:23]1[cH:24][c:25](-[c:31]2[cH:32][c:33]([C:38](=[O:39])[O:40][CH3:41])[c:34](=[O:37])[n:35]([CH2:47][c:46]3[cH:45][cH:44][c:43]([Cl:42])[cH:50][cH:49]3)[n:36]2)[cH:26][cH:27][c:28]1[O:29][CH3:30]

Participants

4

Reactant 3

HCID 77231-Chloro-4-(chloromethyl)benzeneHCID 219914326-(3-fluoro-4-methoxyphenyl)-4-methoxycarbonyl-2H-pyridazin-3-oneHCID 219916626-(2,4-difluorophenyl)-4-hydroxymethyl-2-isobutyl-2H-pyridazin-3-one

Product 1

HCID 219915112-(4-chlorobenzyl)-6-(3-fluoro-4-methoxyphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one

Sources & evidence

ORD record
ord-f028acb04a194acca49da792cf7f25c3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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