HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 2-[2-Ethoxy-5-(1-methylimidazole-4-sulfonylamino)phenyl]-5-methyl-7-cyclopentyl-3H-imidazo-[5,1-f][1,2,4]-triazin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 1-methyl-1H-imidazole-4-sulfonyl chloride | HCID 2736887 | — |
| Reactant | 2-(5-Amino-2-ethoxyphenyl)-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one | HCID 135604941 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-[2-Ethoxy-5-(1-methylimidazole-4-sulfonylamino)phenyl]-5-methyl-7-cyclopentyl-3H-imidazo-[5,1-f][1,2,4]-triazin-4-one | HCID 135604970 | — |
Reaction Steps
150 mg (0.424 mmol) of the compound from example 42A are reacted with 307 mg (1.70 mmol) of 1-methylimidazole-4-sulfonyl chloride and 0.34 ml (4.24 mmol) of pyridine in 5 ml of tetrahydrofuran.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07098207B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-7afd0643970c4a04875dffee36f30101 |
| Source note | uspto-grants-2006_08 |