HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 2-[5-(Quinoline-8-sulfonamido)-2-propoxyphenyl]-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 8-Quinolinesulfonyl chloride | HCID 29220 | — |
| Reactant | 2-(5-Amino-2-propoxyphenyl)-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one | HCID 135604925 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-[5-(Quinoline-8-sulfonamido)-2-propoxyphenyl]-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one | HCID 135604942 | — |
Reaction Steps
150 mg (0.408 mmol) of the compound from example 44A are reacted with 221 mg (0.96 mmol) of quinoline-8-sulfonyl chloride and 0.33 ml (4.08 mmol) of pyridine in 8 ml of tetrahydrofuran overnight.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07098207B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-83fb6179414c4b0e8890d174f5a96b0d |
| Source note | uspto-grants-2006_08 |