Pyridine → 2-[5-(3,4-Dimethoxyphenylacetylamino)-2-ethoxyphenyl]-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one

Participants

Role	Name	HCID	Charge
Reactant	Pyridine	HCID 1049	—
Reactant	(3,4-Dimethoxyphenyl)acetyl chloride	HCID 3604458	—
Reactant	2-(5-Amino-2-ethoxyphenyl)-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one	HCID 135604941	—
Solvent	Tetrahydrofuran	HCID 8028	—
Product	2-[5-(3,4-Dimethoxyphenylacetylamino)-2-ethoxyphenyl]-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one	HCID 135604951	—

Reaction Steps

Analogously to the preparation of example 46, 100 mg (0.283 mmol) of the compound from example 42A are reacted with 182 mg (0.849 mmol) of 3,4-dimethoxyphenylacetyl chloride and 0.23 ml (2.84 mmol) of pyridine in 6 ml of tetrahydrofuran.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07098207B2
Source dataset	uspto-grants-2006_08
ORD ID	ord-0d637d190c36455992e0de19f9749e14
Source note	uspto-grants-2006_08