2-Butenoic acid, ethyl ester → Ethyl 3-(4-amino-2-fluorophenyl)but-2-enoate

HRID 1130780

Reaction equation

HRID 1130780 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([NH2:6])[cH:7][c:8]1[F:9].[C:10]([O:11][CH2:12][CH3:13])(=[O:14])[CH:15]=[CH:16][CH3:17].[NH2:18][c:19]1[cH:20][c:21]([F:34])[c:22]([C:26](=[CH:27][C:28](=[O:29])[O:30][CH2:31][CH3:32])[CH3:33])[cH:23][c:24]1[F:25]>>[NH2:18][c:19]1[cH:20][c:21]([F:34])[c:22]([C:26](=[CH:27][C:28](=[O:29])[O:30][CH2:31][CH3:32])[CH3:33])[cH:23][cH:24]1

Participants

4

Reactant 3

HCID 121912-Butenoic acid, ethyl esterHCID 8218484-Bromo-3-fluoroanilineHCID 91038933Ethyl 3-(4-amino-2,5-difluorophenyl)but-2-enoate

Product 1

HCID 90831084Ethyl 3-(4-amino-2-fluorophenyl)but-2-enoate

Sources & evidence

ORD record
ord-af971d9bdcf64c738974f09c9dc0ed4d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Linked notes

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