tert-Butyl (3-amino-2'-fluoro-[1,1'-biphenyl]-4-yl)carbamate → (2'-Fluoro-3-{3-[2-(4-methyl-imidazol-1-yl)-thiazol-4-yl]-3-oxo-propionylamino}-biphenyl-4-yl)-carbamic acid tert.-butyl ester
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][c:8]1[c:9]([NH2:21])[cH:10][c:11](-[c:14]2[c:15]([F:20])[cH:16][cH:17][cH:18][cH:19]2)[cH:12][cH:13]1)=[O:22].[C:23]([CH3:25])([CH3:26])([O:27][C:28](=[O:24])[CH2:29][C:30](=[O:31])[c:32]1[n:33][c:34](-[n:37]2[cH:38][n:39][c:40]([CH3:42])[cH:41]2)[s:35][cH:36]1)[CH3:43]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][c:8]1[c:9]([NH:21][C:28](=[O:27])[CH2:29][C:30](=[O:31])[c:32]2[n:33][c:34](-[n:37]3[cH:38][n:39][c:40]([CH3:42])[cH:41]3)[s:35][cH:36]2)[cH:10][c:11](-[c:14]2[c:15]([F:20])[cH:16][cH:17][cH:18][cH:19]2)[cH:12][cH:13]1)=[O:22]Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-e126b46f07eb4a9e96f44b8c7ddb2359
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)