Methanol → 4-Aminomethyl-N-(4-chloro-phenyl)-3,N-dimethyl-benzamide

Reaction equation

[BH4-:21].[CH3:23][OH:24].[Cl:1][c:2]1[cH:3][cH:4][c:5]([N:8]([C:9]([c:10]2[cH:11][c:12]([CH3:18])[c:13]([C:16]#[N:17])[cH:14][cH:15]2)=[O:19])[CH3:20])[cH:6][cH:7]1.[Co:31]([Cl:32])[Cl:33].[Na+:22].[OH2:25].[OH2:26].[OH2:27].[OH2:28].[OH2:29].[OH2:30]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([N:8]([C:9]([c:10]2[cH:11][c:12]([CH3:18])[c:13]([CH2:16][NH2:17])[cH:14][cH:15]2)=[O:19])[CH3:20])[cH:6][cH:7]1

Participants

Reactant 6

HCID 887Methanol

HCID 923Sodium Ion

HCID 962Water6×

HCID 24288Cobalt(II) chloride

HCID 28123Borohydride

HCID 57555280N-(4-chloro-phenyl)-4-cyano-3,N-dimethyl-benzamide

Product 1

HCID 575552204-Aminomethyl-N-(4-chloro-phenyl)-3,N-dimethyl-benzamide

Sources & evidence

ORD record: ord-bead953710634dcaa32db55d7056928f
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (7/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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