4-Aminomethyl-3-phenoxy-benzonitrile → (RS)-N-(4-cyano-2-phenoxy-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-ethoxy-acetamide

HRID 1142709

Reaction equation

HRID 1142709 reaction equation
[F:1][c:2]1[c:3]([CH:11]([C:12](=[O:13])[OH:14])[O:15][CH2:16][CH3:17])[c:4]([F:10])[cH:5][c:6]([O:8][CH3:9])[cH:7]1.[NH2:18][CH2:19][c:20]1[c:21]([O:28][c:29]2[cH:30][cH:31][cH:32][cH:33][cH:34]2)[cH:22][c:23]([C:24]#[N:25])[cH:26][cH:27]1>>[F:1][c:2]1[c:3]([CH:11]([C:12](=[O:14])[NH:18][CH2:19][c:20]2[c:21]([O:28][c:29]3[cH:30][cH:31][cH:32][cH:33][cH:34]3)[cH:22][c:23]([C:24]#[N:25])[cH:26][cH:27]2)[O:15][CH2:16][CH3:17])[c:4]([F:10])[cH:5][c:6]([O:8][CH3:9])[cH:7]1

Participants

3

Reactant 2

HCID 219056924-Aminomethyl-3-phenoxy-benzonitrileHCID 21905754(RS)-(2,6-Difluoro-4-methoxy-phenyl)-ethoxy-acetic acid

Product 1

HCID 21905601(RS)-N-(4-cyano-2-phenoxy-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-ethoxy-acetamide

Sources & evidence

ORD record
ord-ab4f6eec672d4d3d8f0d5d40c54fd39f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Linked notes

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