Dimethyl Sulfoxide → tert-butyl N-[2-[[6-(3-aminopyrrolidin-1-yl)pyridine-3-carbonyl]amino]phenyl]carbamate

HRID 114473

Reaction equation

[CH3:31][S:32]([CH3:33])=[O:34].[Cl:1][c:2]1[n:3][cH:4][c:5]([C:6](=[O:7])[NH:8][c:9]2[c:10]([NH:15][C:16]([O:17][C:18]([CH3:19])([CH3:20])[CH3:21])=[O:22])[cH:11][cH:12][cH:13][cH:14]2)[cH:23][cH:24]1.[NH2:25][CH:26]1[CH2:27][NH:28][CH2:29][CH2:30]1.[OH2:35]>>[c:2]1([N:28]2[CH2:27][CH:26]([NH2:25])[CH2:30][CH2:29]2)[n:3][cH:4][c:5]([C:6](=[O:7])[NH:8][c:9]2[c:10]([NH:15][C:16]([O:17][C:18]([CH3:19])([CH3:20])[CH3:21])=[O:22])[cH:11][cH:12][cH:13][cH:14]2)[cH:23][cH:24]1

Participants

Reactant 4

HCID 679Dimethyl Sulfoxide

HCID 962Water

HCID 1644013-Aminopyrrolidine

HCID 57717462tert-Butyl 2-(6-chloronicotinamido)phenylcarbamate

Product 1

HCID 72566975tert-butyl N-[2-[[6-(3-aminopyrrolidin-1-yl)pyridine-3-carbonyl]amino]phenyl]carbamate

Sources & evidence

ORD record: ord-39914cd952ac4436bd0b0be2eae65ea9
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

Linked notes

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