HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1149Generated: October 23, 2026
4'-Fluoroacetophenone → 2,4-Bis(4-fluorophenyl)quinoline
https://huagongshe.com/en/reaction/1149
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4'-Fluoroacetophenone | HCID 9828 | — |
| Reactant | 2-Amino-4'-fluorobenzophenone | HCID 9837287 | — |
| Reactant | 2-Methylbenzenesulfonic acid hydrate | HCID 12496995 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2,4-Bis(4-fluorophenyl)quinoline | HCID 19694816 | — |
Reaction Steps
A flask is loaded with (17) (21.5 g, 0.1 mol), 4-fluoroacetophenone (13.8 g, 0.1 mol), and toluene sulfonic acid monohydrate (3.8 g, 0.02 mol). The flask is heated to 200° C. and the water of condensation removed. After water evolution ceased, the mixture is cooled and the crude solid product is crushed and washed with hot ethanol The product is further recrystallized from toluene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05723573 |
|---|
| Source dataset | uspto-grants-1998_03 |
|---|
| ORD ID | ord-505bc94ed0b24d42b247b9173702273a |
|---|
| Source note | uspto-grants-1998_03 |
|---|
