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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 11519Generated: October 26, 2026

3-(Diethylamino)-1-propanol → Diethyl-[3-(2-fluoro-4-nitro-phenoxy)-propyl]-amine

https://huagongshe.com/reaction/11519

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Diethylamino)-1-propanolHCID 12159—
Reactant1,2-Difluoro-4-nitrobenzeneHCID 123053—
ProductDiethyl-[3-(2-fluoro-4-nitro-phenoxy)-propyl]-amineHCID 21974931—

Reaction Steps

In a manner similar to that described in Example 231a, 3,4-difluoronitrobenzene (6.7 mL, 60.6 mmol, 1 equiv.) and 3-diethylamino-1-propanol (9 mL, 1 equiv.) are converted to the named compound as a brown oil (16.3 g).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07098236B2
Source datasetuspto-grants-2006_08
ORD IDord-56b3fcc70da64331a887512e770547de
Source noteuspto-grants-2006_08