4-Cyanobenzoyl chloride → N-[(3RS,4SR)-4-(4-chloro-phenyl)-1-(4-cyano-benzoyl)-pyrrolidin-3-yl]-4-methoxy-N-methyl-3-trifluoromethyl-benzamide

HRID 1152922Notes

Reaction equation

HRID 1152922 reaction equation
[C:29](#[N:30])[c:31]1[cH:32][cH:33][c:34]([C:35](=[O:36])[Cl:37])[cH:38][cH:39]1.[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[CH:9]([N:13]([C:14]([c:15]3[cH:16][c:17]([C:23]([F:24])([F:25])[F:26])[c:18]([O:21][CH3:22])[cH:19][cH:20]3)=[O:27])[CH3:28])[CH2:10][NH:11][CH2:12]2)[cH:6][cH:7]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[CH:9]([N:13]([C:14]([c:15]3[cH:16][c:17]([C:23]([F:24])([F:25])[F:26])[c:18]([O:21][CH3:22])[cH:19][cH:20]3)=[O:27])[CH3:28])[CH2:10][N:11]([C:35]([c:34]3[cH:33][cH:32][c:31]([C:29]#[N:30])[cH:39][cH:38]3)=[O:36])[CH2:12]2)[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 801724-Cyanobenzoyl chlorideHCID 67025659N-[(3RS,4SR)-4-(4-Chloro-phenyl)-pyrrolidin-3-yl]-4-methoxy-N-methyl-3-trifluoromethyl-benzamide

Product 1

HCID 67025651N-[(3RS,4SR)-4-(4-chloro-phenyl)-1-(4-cyano-benzoyl)-pyrrolidin-3-yl]-4-methoxy-N-methyl-3-trifluoromethyl-benzamide

Sources & evidence

ORD record
ord-8cf128491a0d42679c157b1a2875021d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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