Methanol → Tert-butyl 4-(aminomethyl)-3-methoxypiperidine-1-carboxylate

Reaction equation

[C+4:23].[CH3:20][OH:21].[N:1](=[N+:2]=[N-:3])[CH2:4][CH:5]1[CH:6]([O:18][CH3:19])[CH2:7][N:8]([C:11](=[O:12])[O:13][C:14]([CH3:15])([CH3:16])[CH3:17])[CH2:9][CH2:10]1.[OH-:22].[OH-:25].[OH-:26].[OH-:27].[OH-:28].[OH-:29].[Pd+2:24]>>[NH2:1][CH2:4][CH:5]1[CH:6]([O:18][CH3:19])[CH2:7][N:8]([C:11](=[O:12])[O:13][C:14]([CH3:15])([CH3:16])[CH3:17])[CH2:9][CH2:10]1

Participants

Reactant 5

HCID 887Methanol

HCID 961Hydroxide6×

HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)

HCID 57131955Tert-butyl 4-(azidomethyl)-3-methoxypiperidine-1-carboxylate

HCID 178420935HCID 178420935, compound

Product 1

HCID 22708830Tert-butyl 4-(aminomethyl)-3-methoxypiperidine-1-carboxylate

Sources & evidence

ORD record: ord-c0e581e0f9e340729cc6347827209beb
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (7/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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