Methanol → 4-Amino-3,5-dimethyl-3-ethylpiperidine

Reaction equation

[CH3:19][OH:20].[H:21][H:22].[NH2:1][CH:2]1[C:3]([CH2:16][CH3:17])([CH3:18])[CH2:4][N:5]([CH2:9][c:10]2[cH:11][cH:12][cH:13][cH:14][cH:15]2)[CH2:6][CH:7]1[CH3:8].[OH-:23].[OH-:24].[Pd+2:25]>>[NH2:1][CH:2]1[C:3]([CH2:16][CH3:17])([CH3:18])[CH2:4][NH:5][CH2:6][CH:7]1[CH3:8]

Participants

Reactant 5

HCID 887Methanol

HCID 961Hydroxide2×

HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)

HCID 102145914-Amino-1-benzyl-3,5-dimethyl-3-ethylpiperidine

HCID 178418361HCID 178418361, compound

Product 1

HCID 101250824-Amino-3,5-dimethyl-3-ethylpiperidine

Sources & evidence

ORD record: ord-e8f8516dcad942a089bce46fe5c705a3
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (7/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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