Dichloromethane → N-(3-imidazol-1-ylpropyl)furan-2-carboxamide
Reaction equation
Cl.Cl.[N:3]1([CH2:8][CH2:9][CH2:10][NH2:11])[CH:7]=[CH:6][N:5]=[CH:4]1.[OH-:12].[Na+].[O:14]1[CH:18]=[CH:17][CH:16]=[C:15]1Cl.Cl[CH2:21]Cl>>[N:3]1([CH2:8][CH2:9][CH2:10][NH:11][C:21]([C:15]2[O:14][CH:18]=[CH:17][CH:16]=2)=[O:12])[CH:7]=[CH:6][N:5]=[CH:4]1Participants
5
Procedure
A mixture of 1.98 g. of 1H-imidazole-1-propanamine dihydrochloride and 30 ml. of 1N sodium hydroxide was stirred at room temperature. A mixture of 0.98 ml. of 2-furanyl chloride and 50 ml. of dichloromethane was added and stirring was continued overnight. More dichloromethane was added, the organic layer was separated, washed twice with water and concentrated, giving 1.0 g. of the desired product, m.p. 111°-113° C.