4-Fluorobenzoyl chloride → 1-(4-Fluorobenzoylamino)-2-(2-methylphenyl)ethane

Reaction equation

[NH2:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH3:10].[F:11][C:12]1[CH:20]=[CH:19][C:15]([C:16](Cl)=[O:17])=[CH:14][CH:13]=1>>[F:11][C:12]1[CH:20]=[CH:19][C:15]([C:16]([NH:1][CH2:2][CH2:3][C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[CH3:10])=[O:17])=[CH:14][CH:13]=1

Participants

Reactant 2

HCID 678794-Fluorobenzoyl chloride

HCID 20638682-Methylphenethylamine

Product 1

HCID 128518101-(4-Fluorobenzoylamino)-2-(2-methylphenyl)ethane

Procedure

1-Amino-2-(2-methylphenyl)ethane was reacted with 4-fluorobenzoyl chloride in the same way as in step (a) of Example 1 to afford 1-(4-fluorobenzoylamino)-2-(2-methylphenyl)ethane as colorless needles having a melting point of 82° to 83° C.

Sources & evidence

ORD record: ord-664993288dc9440389d86bd15832ef3f
Source dataset: uspto-grants-1982_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04337256

Reaction notes

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