1-(4-Chlorophenyl)isoquinoline-5-acetonitrile → 1-(4-Methoxyphenyl)isoquinoline-5-acetonitrile
Reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:18]3[C:13](=[C:14]([CH3:19])[CH:15]=[CH:16][CH:17]=3)[CH:12]=[CH:11][N:10]=2)=[CH:5][CH:4]=1.ClC1C=CC([C:27]2C3C=CC=C(CC#N)C=3C=C[N:28]=2)=CC=1>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[C:18]3[CH:17]=[CH:16][CH:15]=[C:14]([CH2:19][C:27]#[N:28])[C:13]=3[CH:12]=[CH:11][N:10]=2)=[CH:7][CH:8]=1Participants
3
Procedure
1-(4-Methoxyphenyl)-5-methylisoquinoline was reacted successively in the same way as in steps (d) and (e) of Example 1 to afford 1-(4-methoxyphenyl)isoquinoline-5-acetonitrile as slightly yellow scales having a melting point of 130.5° to 132.0° C.
Sources & evidence
- ORD record
- ord-4e3ddcd749b6466da3f0f838f924f74c
- Source dataset
- uspto-grants-1982_06