Acetonitrile → N-(1-Hydroxymethyl-cyclopentyl)-acetamide
Reaction equation
[OH:1][CH2:2][C:3]([NH:6][C:7](=[O:9])[CH3:8])([CH3:5])[CH3:4].N[C:11]1(CO)CCC[CH2:12]1.CC#N.O.CC#N>O>[OH:1][CH2:2][C:3]1([NH:6][C:7](=[O:9])[CH3:8])[CH2:5][CH2:12][CH2:11][CH2:4]1Participants
6
Procedure
The title compound is prepared analogously as described for N-(2-hydroxy-1,1-dimethyl-ethyl)-acetamide from (1-amino-cyclopentyl)-methanol. MS (LC-MS): [M+H]+=158.2. tR (HPLC, Waters sun fire C18 column, 5-95% CH3CN/H2O/3.5 min, 95% CH3CN/H2O, 2 min, CH3CN and H2O containing 0.1% TFA, flow: 0.8 mL/min): 1.76 min.
Workup
- custom1.76 min.
Sources & evidence
- ORD record
- ord-4df8cbef7df34100b313c51baee24463
- Source dataset
- uspto-grants-2010_10
- Patent number
- US07807709B2
Reaction notes
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