Acetonitrile → Carbamic chloride, N-ethyl-N-(phenylmethyl)-

HRID 1158437Notes

Reaction equation

HRID 1158437 reaction equation
[CH2:1]([N:8]([CH3:12])[C:9]([Cl:11])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:13](NCC)C1C=CC=CC=1.CC#N.O.CC#N>O>[CH2:1]([N:8]([CH2:12][CH3:13])[C:9]([Cl:11])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 6342AcetonitrileHCID 84352N-EthylbenzylamineHCID 10464985N-benzyl-N-methylcarbamoyl chlorideHCID 18373917Acetonitrile--water (1/1)2×

Product 1

HCID 10679448Carbamic chloride, N-ethyl-N-(phenylmethyl)-

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The title compound is prepared analogously as described for benzyl-methyl-carbamoyl chloride from benzyl ethylamine. MS (LC-MS): [M+H]+=198.1. tR (HPLC, Waters Symmetry C18 column, 20-95% CH3CN/H2O/3.5 min, 95% CH3CN/H2O, 2 min, CH3CN and H2O containing 0.1% TFA, flow: 0.6 mL/min): 4.12 min.

Workup

  1. custom4.12 min.

Sources & evidence

ORD record
ord-47c738335f46429ebba8e9c517f0ea16
Source dataset
uspto-grants-2010_10
Patent number
US07807709B2

Reaction notes

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