Ammonium Chloride → HCID 178425624, compound
Reaction equation
[CH3:1][C:2]1([CH3:10])[CH2:7][CH2:6][C:5](OC)=[N:4][CH2:3]1.[Cl-:11].[NH4+:12]>C(O)C>[ClH:11].[CH3:1][C:2]1([CH3:10])[CH2:3][NH:4][C:5](=[NH:12])[CH2:6][CH2:7]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
The mixture of 3,3-dimethyl-6-methoxy-2,3,4,5-tetrahydropyridine (9.0 g, 64 mmol) and ammonium chloride (3.4 g, 64 mmol) in dry ethanol (160 mL) was heated to reflux for 2 h. The reaction mixture was then concentrated under reduced pressure and the titled compound was obtained as a white solid (9.9 g, 94.6%).
Workup
- temperaturewas heated
- temperatureto reflux for 2 h
- concentrationThe reaction mixture was then concentrated under reduced pressure
Sources & evidence
- ORD record
- ord-2f0c9aec9ca847ee9650f575ea16b359
- Source dataset
- uspto-grants-2010_10
- Patent number
- US07812014B2
Reaction notes
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