4-Chlorophenylboronic acid → 5-(4-chloro-phenyl)-N-((R)-2-cyclopropyl-2-hydroxy-propyl)-6-cyclopropylmethoxy-nicotinamide

Reaction equation

Br[C:2]1[CH:3]=[C:4]([C:9]([OH:11])=O)[CH:5]=[N:6][C:7]=1Cl.[CH:12]1([CH2:15][OH:16])[CH2:14][CH2:13]1.[Cl:17][C:18]1[CH:23]=[CH:22][C:21](B(O)O)=[CH:20][CH:19]=1.[NH2:27][CH2:28][C@@:29]([CH3:34])([CH:31]1[CH2:33][CH2:32]1)[OH:30]>>[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([C:2]2[C:7]([O:16][CH2:15][CH:12]3[CH2:14][CH2:13]3)=[N:6][CH:5]=[C:4]([CH:3]=2)[C:9]([NH:27][CH2:28][C@@:29]([CH:31]2[CH2:33][CH2:32]2)([OH:30])[CH3:34])=[O:11])=[CH:20][CH:19]=1