4-(4-Chlorophenyl)Imidazole → 4-[5-(4-Chloro-phenyl)-imidazol-1-yl]-2,2-dimethyl-3,4-dihydro-2H-pyrano[3,2-c]pyridin-3-ol
Reaction equation
[CH3:1][C:2]1([CH3:13])[O:11][C:10]2[C:5](=[CH:6][N:7]=[CH:8][CH:9]=2)[CH:4]2[O:12][CH:3]12.[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2[NH:25][CH:24]=[N:23][CH:22]=2)=[CH:17][CH:16]=1>>[Cl:14][C:15]1[CH:16]=[CH:17][C:18]([C:21]2[N:25]([CH:4]3[C:5]4[CH:6]=[N:7][CH:8]=[CH:9][C:10]=4[O:11][C:2]([CH3:13])([CH3:1])[CH:3]3[OH:12])[CH:24]=[N:23][CH:22]=2)=[CH:19][CH:20]=1Participants
3
Procedure
Following the procedure in Example 1, using (±)-2,2-dimethyl-1a,7b-dihydro-2H-1,3-dioxa-6-aza-cyclopropa[a]naphthalene (literature known compound) and 5-(4-chloro-phenyl)-1H-imidazole as starting materials, the title compound was prepare das a pale yellow solid.
Sources & evidence
- ORD record
- ord-3ee72e698efb4926999b752accb11860
- Source dataset
- uspto-grants-2010_10
- DOI