6-Methoxy-m-toluenesulfonyl chloride → 4-Bromo-1-[(2-methoxy-5-methylphenyl)sulfonyl]-1H-indole

HRID 1159756Notes

Reaction equation

HRID 1159756 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[CH:5][N:6]2S(C1C=CC(C)=CC=1)(=O)=O.[CH3:21][O:22][C:23]1[CH:28]=[CH:27][C:26]([CH3:29])=[CH:25][C:24]=1[S:30](Cl)(=[O:32])=[O:31]>>[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[CH:5][N:6]2[S:30]([C:24]1[CH:25]=[C:26]([CH3:29])[CH:27]=[CH:28][C:23]=1[O:22][CH3:21])(=[O:32])=[O:31]

Participants

3

Reactant 2

HCID 1451496-Methoxy-m-toluenesulfonyl chlorideHCID 5628694-Bromo-1-(toluene-4-sulfonyl)-1H-indole

Product 1

HCID 687168404-Bromo-1-[(2-methoxy-5-methylphenyl)sulfonyl]-1H-indole

Procedure

The procedure for Intermediate 3 was followed using (2-methoxy-5-methylphenyl)sulfonyl chloride. Yield 1.4 g (72%). MS (ESI+) for C16H14BrNO3S m/z 382 (M+H)+.

Sources & evidence

ORD record
ord-b5096f3a8d1e4e658724f6b636ebf32a
Source dataset
uspto-grants-2010_10
Patent number
US07812017B2

Reaction notes

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