3-(Chlorosulfonyl)-4-fluorobenzoic acid → (4-Fluoro-3-mercapto-phenyl)-methanol

HRID 1160243Notes

Reaction equation

HRID 1160243 reaction equation
Cl[S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][C:13]=1[F:14])[C:8](O)=[O:9])(=O)=O.SC1C=C(CO)C=CC=1>>[F:14][C:13]1[CH:12]=[CH:11][C:7]([CH2:8][OH:9])=[CH:6][C:5]=1[SH:2]

Participants

3

Reactant 2

HCID 39298913-(Chlorosulfonyl)-4-fluorobenzoic acidHCID 12813879(3-Sulfanylphenyl)methanol

Product 1

HCID 57458792(4-Fluoro-3-mercapto-phenyl)-methanol

Procedure

The required (4-Fluoro-3-mercapto-phenyl)-methanol is prepared in two steps from 3-Chlorosulfonyl-4-fluoro-benzoic acid following the procedure for the preparation of (3-Mercapto-phenyl)-methanol described in Chemistry Express, Vol 7, No. 11, pp. 865-868).

Sources & evidence

ORD record
ord-536c3f24ed80428890950b7ebac84519
Source dataset
uspto-grants-2010_10
Patent number
US07816389B2

Reaction notes

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