Indole-2-carboxylic acid → 3-(Indole-2-carbonylamino)-3,4-dihydrocarbostyril

HRID 11603

Reaction equation

HRID 11603 reaction equation
Cl.[NH2:2][CH:3]1[CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5][C:4]1=[O:13].[NH:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[C:15]1[C:23](O)=[O:24]>>[NH:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[C:15]1[C:23]([NH:2][CH:3]1[CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5][C:4]1=[O:13])=[O:24]

Participants

3

Reactant 2

HCID 72899Indole-2-carboxylic acidHCID 134994283-Amino-3,4-dihydroquinolin-2(1H)-one--hydrogen chloride (1/1)

Product 1

HCID 117798543-(Indole-2-carbonylamino)-3,4-dihydrocarbostyril

Procedure

The title compound was prepared by the methods of Example 5 using 3-amino-3,4-dihydrocarbostyril hydrochloride in place of (R)-3-amino-3,4-dihydrocarbostyril hydrochloride and indole-2-carboxylic acid in place of 5-chloroindole-2-carboxylic acid. HPLC/MS [M+H]+, 306; [M+Na]+, 328.

Sources & evidence

ORD record
ord-5b68b01f24c048a9abcf80baf3ff1997
Source dataset
uspto-grants-2006_08
Patent number
US07098235B2

Linked notes

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