Reaction equation
C[O:2][C:3](=[O:39])[CH2:4][CH2:5][NH:6][C:7](=[O:38])[C:8]1[CH:13]=[CH:12][C:11]([CH:14]([O:22]C2C=CC(B3OC(C)(C)C(C)(C)O3)=CC=2)[CH2:15][CH2:16][CH2:17][C:18]([F:21])([F:20])[F:19])=[CH:10][CH:9]=1.Br[C:41]1[C:46]([C:47]([CH3:50])([CH3:49])[CH3:48])=[CH:45][C:44]([C:51]([CH3:54])([CH3:53])[CH3:52])=[CH:43][C:42]=1[C:55]([CH3:58])([CH3:57])[CH3:56]>>[C:55]([C:42]1[CH:43]=[C:44]([C:51]([CH3:54])([CH3:53])[CH3:52])[CH:45]=[C:46]([C:47]([CH3:50])([CH3:49])[CH3:48])[C:41]=1[O:22][CH:14]([C:11]1[CH:12]=[CH:13][C:8]([C:7]([NH:6][CH2:5][CH2:4][C:3]([OH:39])=[O:2])=[O:38])=[CH:9][CH:10]=1)[CH2:15][CH2:16][CH2:17][C:18]([F:21])([F:20])[F:19])([CH3:58])([CH3:57])[CH3:56]Participants
3
Reactant 2
Product 1
Procedure
The title compound is prepared in a manner substantially similar to Example 359 starting from 3-(4-{5,5,5-trifluoro-1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-pentyl}-benzoylamino)-propionic acid methyl ester and 2-bromo-1,3,5-tri-tert-butyl-benzene. MS: 652.2 [M−H]−.
Sources & evidence
- ORD record
- ord-8d5ca36a0fbf4ccfa8ab418af2b507fb
- Source dataset
- uspto-grants-2010_10
- Patent number
- US07816557B2
Linked notes
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