Cyclopentylthiourea → Cyclopentyl-[4-(4-isopropyl-phenyl)-thiazol-2-yl]-amine

HRID 1162556Notes

Reaction equation

HRID 1162556 reaction equation
[CH:1]1([NH:6][C:7]([NH2:9])=[S:8])[CH2:5][CH2:4][CH2:3][CH2:2]1.Br[CH2:11][C:12]([C:14]1[CH:19]=[CH:18][C:17]([CH:20]([CH3:22])[CH3:21])=[CH:16][CH:15]=1)=O>>[CH:1]1([NH:6][C:7]2[S:8][CH:11]=[C:12]([C:14]3[CH:19]=[CH:18][C:17]([CH:20]([CH3:22])[CH3:21])=[CH:16][CH:15]=3)[N:9]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 736945CyclopentylthioureaHCID 140427562-Bromo-1-(4-(propan-2-yl)phenyl)ethan-1-one

Product 1

HCID 86079884Cyclopentyl-[4-(4-isopropyl-phenyl)-thiazol-2-yl]-amine

Procedure

Cyclopentyl-[4-(4-isopropyl-phenyl)-thiazol-2-yl]-amine was prepared following procedure B using cyclopentyl-thiourea (1.6 g, 10.7 mmol) and 2-bromo-1-(4-isopropyl-phenyl)-ethanone (2.6 g, 10.7 mmol). Purification (Silica gel, ethyl acetate/hexane 5:95) provided the product (2.9 g). LCMS m/z: 287 (M+1)+.

Workup

  1. customPurification (Silica gel, ethyl acetate/hexane 5:95)

Sources & evidence

ORD record
ord-97c1b89297b540d5896490f64fbc0b88
Source dataset
uspto-grants-2010_10
Patent number
US07820704B2

Reaction notes

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