Acetoxyacetic acid → (S)-2-Oxo-3-[1-oxo-3-(2-trifluoromethylphenyl)-1,2-dihydroisoquinolin-7-yl]oxazolidin-5-ylmethyl acetoxyacetate
Reaction equation
[C:1]([O:4][CH2:5][C:6]([OH:8])=[O:7])(=[O:3])[CH3:2].O[CH2:10][C@H:11]1[O:15][C:14](=[O:16])[N:13]([C:17]2[CH:26]=[C:25]3[C:20]([CH:21]=[C:22]([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=4[C:34]([F:37])([F:36])[F:35])[NH:23][C:24]3=[O:27])=[CH:19][CH:18]=2)[CH2:12]1>>[C:1]([O:4][CH2:5][C:6]([O:8][CH2:10][C@H:11]1[O:15][C:14](=[O:16])[N:13]([C:17]2[CH:26]=[C:25]3[C:20]([CH:21]=[C:22]([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=4[C:34]([F:36])([F:35])[F:37])[NH:23][C:24]3=[O:27])=[CH:19][CH:18]=2)[CH2:12]1)=[O:7])(=[O:3])[CH3:2]Participants
3
Procedure
The title compound was synthesized by a condensation method similar to that of Step A of Example 3-1 using acetoxyacetic acid instead of Boc-Sar-OH and 7-((S)-5-hydroxymethyl-2-oxooxazolidin-3-yl)-3-(2-trifluoromethylphenyl)-2H-isoquinolin-1-one obtained in Step B of Example 1-13 instead of 7-((R)-5-hydroxymethyl-2-oxooxazolidin-3-yl)-3-(2-trifluoromethylphenyl)-2H-isoquinolin-1-one obtained in Step B of Example 1-14.