HuagongsheHuagongshe Chemistry Print Report · For research reference only
Levulinic Acid → 9-Methoxy-11b-methyl-1,2,5,6,11,11b-hexahydro-indolizino[8,7-b]indol-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Levulinic Acid | HCID 11579 | — |
| Reactant | 2-(2-Aminoethyl)-5-methoxyindole | HCID 17654 | — |
| Solvent | 1-Ethoxyethanol | HCID 10129898 | — |
| Product | 9-Methoxy-11b-methyl-1,2,5,6,11,11b-hexahydro-indolizino[8,7-b]indol-3-one | HCID 58970766 | 71.8% |
Reaction Steps
A mixture of 6-methoxytryptamine (0.95 g, 5 mmol) and levulinic acid (0.7 g, 6 mmol) in ethoxyethanol is heated at ruflux temperature for 16 hours, cooled to room temperature and concentrated in vacuo to give 9-methoxy-11b-methyl-1,2,5,6,11,11b-hexahydro-indolizino[8,7-b]indol-3-one (0.97 g) identified by NMR, HPLC and MS [271.2 m/e (M+H)].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07820825B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-d1b0d087b438454ba17e4ca35b4036b7 |
| Source note | uspto-grants-2010_10 |