Acetic Anhydride → HCID 12803438, compound

Reaction equation

[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[NH:7][C:6]1=[O:16].[C:17](OC(=O)C)(=[O:19])[CH3:18]>>[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[N:7]([C:17](=[O:19])[CH3:18])[C:6]1=[O:16]

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 12803422HCID 12803422, compound

Product 1

HCID 12803438HCID 12803438, compound

Procedure

Approximately 21.8 g of 1-(2-methoxyethyl)-4-phenyl-4-imidazolin-2-one and 120 ml. of acetic anhydride is refluxed together for four hours. The acetic anhydride is distilled out at reduced pressure. The residual semisolid is recrystallized from ether to yield the title compound as a white solid; m.p. 73°-75° C.

Workup

distillationThe acetic anhydride is distilled out at reduced pressure
customThe residual semisolid is recrystallized from ether

Sources & evidence

ORD record: ord-63bbde97d2e74ebcad835a8ab14d62ec
Source dataset: uspto-grants-1983_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04370482

Reaction notes

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