Bromine → 2-Bromo-1-(4-chlorophenyl)hexan-1-one
Reaction equation
[Br:1]Br.[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([C:10](=[O:16])[CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])=[CH:6][CH:5]=1>C(OCC)C>[Br:1][CH:11]([CH2:12][CH2:13][CH2:14][CH3:15])[C:10]([C:7]1[CH:6]=[CH:5][C:4]([Cl:3])=[CH:9][CH:8]=1)=[O:16]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Bromine (0.02 mol) was added dropwise to a stirred solution of 4'-chlorohexanophenone (0.02 mol) in dry diethyl ether (20 ml) at 10°-20° over one hour. The ether was then removed in vacuo from the reaction mixture to leave a pale-yellow liquid which on distillation gave 2-bromo-4'-chlorohexanophenone, b.p. 124°-126°/0.04 mm Hg.
Workup
- customThe ether was then removed in vacuo from the reaction mixture
- customto leave a pale-yellow liquid which
- distillationon distillation
Sources & evidence
- ORD record
- ord-0bf2686b82d84a4a8c8d3ab7d1d69d30
- Source dataset
- uspto-grants-1990_03
- Patent number
- US04912121
Reaction notes
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