Glyoxal → Glyoxal guanine

HRID 1167596

Reaction equation

HRID 1167596 reaction equation
[NH:1]1[C:10](=[O:11])[C:9]2[NH:8][CH:7]=[N:6][C:5]=2[N:4]=[C:2]1[NH2:3].[CH:12]([CH:14]=[O:15])=[O:13]>O>[CH:12]([CH:14]=[O:15])=[O:13].[NH:1]1[C:10](=[O:11])[C:9]2[NH:8][CH:7]=[N:6][C:5]=2[N:4]=[C:2]1[NH2:3]

Participants

4

Reactant 2

HCID 7860GlyoxalHCID 135398634Guanine

Product 1

HCID 136394281Glyoxal guanine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
70 °C

Procedure

22.65 g of guanine (manufactured by Tokyo Kasei Kogyo Co.,) and 21.75 g of a 40% glyoxal aqueous solution (manufactured by Tokyo Kasei Kogyo Co.,) were added to 950 mL of purified water, and the mixture was stirred with heating at 70° C. for 18 hours. The mixture was then cooled to 40° C. and filtered. The white solid obtained by the filtration was dried, thereby resulting in 30.7 g of glyoxal-guanine. The measurement result of nuclear magnetic resonance (NMR) spectrum is as follows.

Workup

  1. temperatureThe mixture was then cooled to 40° C.
  2. filtrationfiltered
  3. customThe white solid obtained by the filtration
  4. customwas dried
  5. customresulting in 30.7 g of glyoxal-guanine
  6. customThe measurement result of nuclear magnetic resonance (NMR) spectrum

Sources & evidence

ORD record
ord-84e5a409f34041e794c41e7a021e5321
Source dataset
uspto-grants-2003_09
Patent number
US06620596B2

Linked notes

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