Acetyl chloride → HCID 10288184, compound

Reaction equation

[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH:12][C:13](=[O:22])[C:14]3[CH:19]=[CH:18][C:17]([CH2:20][NH2:21])=[CH:16][CH:15]=3)[S:11][C:7]=2[C:6]([N:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)=[CH:5][CH:4]=1.[C:29](Cl)(=[O:31])[CH3:30]>>[C:29]([NH:21][CH2:20][C:17]1[CH:18]=[CH:19][C:14]([C:13]([NH:12][C:10]2[S:11][C:7]3[C:6]([N:23]4[CH2:28][CH2:27][O:26][CH2:25][CH2:24]4)=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[C:8]=3[N:9]=2)=[O:22])=[CH:15][CH:16]=1)(=[O:31])[CH3:30]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 11280971HCID 11280971, compound

Product 1

HCID 10288184HCID 10288184, compound

Procedure

Using N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-4-aminomethyl-benzamide and acetyl chloride, the title compound was prepared as white crystals (17% yield). MS: m/e=441(M+H+).

Sources & evidence

ORD record: ord-7f137051d642444696b9303cf2f6f643
Source dataset: uspto-grants-2003_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06624163B2

Reaction notes

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