2,2'-(1-Benzylpiperidine-4,4-diyl)diethanol → 2-[4-(2-Hydroxyethyl)piperidin-4-yl]ethan-1-ol
Reaction equation
C([N:8]1[CH2:13][CH2:12][C:11]([CH2:17][CH2:18][OH:19])([CH2:14][CH2:15][OH:16])[CH2:10][CH2:9]1)C1C=CC=CC=1>C(O)C.[Pd]>[OH:19][CH2:18][CH2:17][C:11]1([CH2:14][CH2:15][OH:16])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
4,4-bis-(2-hydroxyethyl)piperidine is prepared by catalytic hydrogenation of 1-benzyl-4,4-bis-(2-hydroxyethyl)piperidine in ethanol in the presence of palladium on activated carbon (10% Pd).
Sources & evidence
- ORD record
- ord-49bb4d4cffe54e10b84f659dc88a1162
- Source dataset
- uspto-grants-2003_09
- Patent number
- US06627634B2
Reaction notes
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