2-Thiopheneboronic acid → 3-(2-Chloro-5-thiophen-2-yl-pyrimidin-4-yloxy)-propionic acid tert-butyl ester

Reaction equation

[C:1]([O:5][C:6](=[O:18])[CH2:7][CH2:8][O:9][C:10]1[C:15](Br)=[CH:14][N:13]=[C:12]([Cl:17])[N:11]=1)([CH3:4])([CH3:3])[CH3:2].[S:19]1[CH:23]=[CH:22][CH:21]=[C:20]1B(O)O>>[C:1]([O:5][C:6](=[O:18])[CH2:7][CH2:8][O:9][C:10]1[C:15]([C:20]2[S:19][CH:23]=[CH:22][CH:21]=2)=[CH:14][N:13]=[C:12]([Cl:17])[N:11]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 27339602-Thiopheneboronic acid

HCID 595508803-(5-Bromo-2-chloro-pyrimidin-4-yloxy)-propionic acid tert-butyl ester

Product 1

HCID 589857663-(2-Chloro-5-thiophen-2-yl-pyrimidin-4-yloxy)-propionic acid tert-butyl ester

Procedure

Preparation according to procedure 11a with the use of 3-(5-Bromo-2-chloro-pyrimidin-4-yloxy)-propionic acid tert-butyl ester and 2-thienyl-boronic-acid.

Workup

customPreparation

Sources & evidence

ORD record: ord-dc5b7978fc414ef1b303525eb3c67453
Source dataset: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07825128B2

Reaction notes

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