Reaction equation
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]([NH:16][C:17](=[O:31])[C:18]2[CH:23]=[C:22]([N:24]3[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]3)[CH:21]=[C:20]([F:30])[CH:19]=2)=[CH:8][CH:7]=1.[C:32]([N:35]1[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]1)(=[O:34])[CH3:33]>>[C:32]([N:35]1[CH2:40][CH2:39][N:38]([CH2:2][CH2:3][CH2:4][O:5][C:6]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]([NH:16][C:17](=[O:31])[C:18]3[CH:23]=[C:22]([N:24]4[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]4)[CH:21]=[C:20]([F:30])[CH:19]=3)=[CH:8][CH:7]=2)[CH2:37][CH2:36]1)(=[O:34])[CH3:33]Participants
3
Procedure
Compound is prepared from N-[4-(3-chloropropoxy)-naphthalen-1-yl]-3-fluoro-5-piperidin-1-yl-benzamide and N-acetylpiperizine according to conditions described in general procedure L. A white powder (0.13 g, 75.5%). Mp: 210-211° C. 1H NMR (300 MHz, DMSO-d6) δ 10.23 (s, 1H), 8.22 (br s, 1H), 7.84 (br s, 1H), 7.55 (m, 2H), 7.44 (m, 2H), 7.15 (br s, 1H), 6.98 (br s, 2H), 4.23 (br s, 2H), 3.42 (br s, 4H), 3.30 (br s, 4H), 2.57 (br s, 2H), 2.42 (m, 4H), 2.04 (m, 2H), 1.98 (s, 3H), 1.60 (br s, 6H). MS: 533.5 (M+1).
Sources & evidence
- ORD record
- ord-8fa8514a06e6494a9912660871a214dd
- Source dataset
- uspto-grants-2010_11
- Patent number
- US07829560B2
Linked notes
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