Ethanol → HCID 86245030, compound
Reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[CH2:11][C:12]([OH:14])=[O:13].S(=O)(=O)(O)O.[CH2:20](O)[CH3:21]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[CH2:11][C:12]([O:14][CH2:20][CH3:21])=[O:13]Participants
4
Procedure
A mixture composed of 5.21 g (20 mmol) of (2-bromo-5-nitrophenyl)acetic acid (Zhumal Organicheskoi Khimii (1974) 10, 92-5), 80 ml of absolute ethanol and 0.1 ml of concentrated sulfuric acid is refluxed for 6 hours. After cooling, the reaction medium is concentrated under vacuum and taken up in ether. This organic phase is washed with saturated NaHCO3 solution and then with water, after which it is dried over Na2SO4. After concentrating under vacuum, 5.54 g of a beige solid are obtained.
Workup
- temperature