N-{6-[(Phenylmethyl)oxy]-3-pyridinyl}acetamide → HCID 178474274, compound
Reaction equation
C1(C[O:8][C:9]2[N:14]=[CH:13][C:12]([NH:15][C:16](=[O:18])[CH3:17])=[CH:11][CH:10]=2)C=CC=CC=1>CCO.[Pd]>[OH:8][C:9]1[N:14]=[CH:13][C:12]([NH:15][C:16](=[O:18])[CH3:17])=[CH:11][CH:10]=1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
To a solution of N-{6-[(phenylmethyl)oxy]-3-pyridinyl}acetamide (0.210 g, 0.87 mmol) in EtOH (10 mL) at rt was added Pd—C (0.046 g of 10 wt % on activated carbon (dry basis), ca. 50 wt % H2O; ca. 0.022 mmol Pd). The mixture was placed under an atmosphere of H2 and stirred for 4.5 h. The mixture was filtered through Celite (EtOAc wash) and concentrated in vacuo, affording 0.132 g of the title compound as a colorless solid: MS (ESI) m/z 152 (M+).
Workup
- filtrationThe mixture was filtered through Celite (EtOAc wash)
- concentrationconcentrated in vacuo
Sources & evidence
- ORD record
- ord-6253c988063c46f6b92abd8d073f19a3
- Source dataset
- uspto-grants-2010_11
- Patent number
- US07834063B2
Reaction notes
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