Piperidine, 1-(2-chloroethyl)-, hydrochloride → Methyl-(6-nitro-benzothiazol-2-yl)-(2-piperidin-1-yl-ethyl)-amine

HRID 1174962Notes

Reaction equation

HRID 1174962 reaction equation
[CH3:1][NH:2][C:3]1[S:4][C:5]2[CH:11]=[C:10]([N+:12]([O-:14])=[O:13])[CH:9]=[CH:8][C:6]=2[N:7]=1.Cl.Cl[CH2:17][CH2:18][N:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>>[CH3:1][N:2]([C:3]1[S:4][C:5]2[CH:11]=[C:10]([N+:12]([O-:14])=[O:13])[CH:9]=[CH:8][C:6]=2[N:7]=1)[CH2:17][CH2:18][N:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 74826Piperidine, 1-(2-chloroethyl)-, hydrochlorideHCID 638568N-Methyl-6-nitrobenzo[D]thiazol-2-amine

Product 1

HCID 57771692Methyl-(6-nitro-benzothiazol-2-yl)-(2-piperidin-1-yl-ethyl)-amine

Procedure

The title compound is prepared according to the general procedure outlined in Example 61, Step 2, utilizing methyl(6-nitro-benzothiazol-2-yl)-amine (979 mg, 4.68 mmol) and N-(2-chloroethyl)-piperidine hydrochloride (2.01 g, 10.92 mmol) to yield 1.43 g (79%) of the product. mass spectrum (ion-spray): (m/z)=321.3 (M+1).

Sources & evidence

ORD record
ord-bc555665845446f3bc46efa0a9d15277
Source dataset
uspto-grants-2010_11
Patent number
US07838543B2

Reaction notes

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