Isobutylamine → HCID 68773492, compound

Reaction equation

[Br:1][C:2]1[CH:3]=[N:4][N:5]([C:7]([CH3:12])([CH3:11])[C:8]([OH:10])=O)[CH:6]=1.[CH2:13]([NH2:17])[CH:14]([CH3:16])[CH3:15]>>[Br:1][C:2]1[CH:3]=[N:4][N:5]([C:7]([CH3:12])([CH3:11])[C:8]([NH:17][CH2:13][CH:14]([CH3:16])[CH3:15])=[O:10])[CH:6]=1

Participants

Reactant 2

HCID 6558Isobutylamine

HCID 70172782-(4-bromopyrazol-1-yl)-2-methylpropanoic acid

Product 1

HCID 68773492HCID 68773492, compoundYield 95%

Procedure

Prepared in a similar manner to Example 3 from 2-(4-bromo-1H-pyrazol-1-yl)-2-methylpropanoic acid and isobutylamine. Yield: 95%. 1H NMR (400 MHz, CDCl3): δ 0.81 (d, 3H, J=6.8 Hz), 1.63-1.67 (m, 1H), 1.84 (s, 6H), 2.99 (t, 2H, J=6.8 Hz), 6.19 (br, 1H), 7.61 (s, 1H), 7.64 (s, 1H). MS(MH+) 288, 290.

Sources & evidence

ORD record: ord-001784a7e83840f89330964dd5dff68f
Source dataset: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07842324B2

Reaction notes

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