(R)-sec-butylamine → (R)-N-sec-butyl-2-(4-(6-cyanopyrazin-2-yl)phenyl)-2-methylpropanamide
Reaction equation
[C:1]([C:3]1[N:8]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([CH3:20])([CH3:19])[C:16]([OH:18])=O)=[CH:11][CH:10]=2)[CH:6]=[N:5][CH:4]=1)#[N:2].[CH3:21][C@@H:22]([NH2:25])[CH2:23][CH3:24]>>[C@H:22]([NH:25][C:16](=[O:18])[C:15]([C:12]1[CH:11]=[CH:10][C:9]([C:7]2[CH:6]=[N:5][CH:4]=[C:3]([C:1]#[N:2])[N:8]=2)=[CH:14][CH:13]=1)([CH3:20])[CH3:19])([CH2:23][CH3:24])[CH3:21]Participants
3
Procedure
Prepared in a similar manner to Example 20 from 2-(4-(6-Cyanopyrazin-2-yl)phenyl)-2-methylpropanoic acid (example 20a) and (R)-butan-2-amine. Yield 43%.
Sources & evidence
- ORD record
- ord-e77ac9e845994dc785bae36886421637
- Source dataset
- uspto-grants-2010_11