1-(3-Phenyl-propyl)-piperidine-4-carboxylic acid benzyl ester → 1-(3-Phenylpropyl)piperidine-4-carboxylic acid
Reaction equation
C([O:8][C:9]([CH:11]1[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:13][CH2:12]1)=[O:10])C1C=CC=CC=1>CO.[Pd]>[C:20]1([CH2:19][CH2:18][CH2:17][N:14]2[CH2:15][CH2:16][CH:11]([C:9]([OH:10])=[O:8])[CH2:12][CH2:13]2)[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
Pd/C (378 mg) was added to a stirred solution of 1-(3-phenyl-propyl)-piperidine-4-carboxylic acid benzyl ester (1.89 g, 5 mmol) in MeOH (38 mL) and stirring was continued under hydrogen atmosphere for 2 hrs. The mixture was filtered over a bed of celite. The celite was washed with MeOH and the filtrate was concentrated under reduced pressure to afford 1.502 mg (93.93% yield) of 1-(3-phenyl-propyl)-piperidine-4-carboxylic acid. LCMS Purity: 95.08%.