Methyl 3-(4-methoxypyridin-2-yl)acrylate → Methyl 3-(4-methoxypyridin-2-yl)propanoate
Reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([CH:9]=[CH:10][C:11]([O:13][CH3:14])=[O:12])[CH:4]=1>CO.[Pd]>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([CH2:9][CH2:10][C:11]([O:13][CH3:14])=[O:12])[CH:4]=1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
43.1 g of methyl 3-(4-methoxypyridin-2-yl)acrylate (starting material D1) in 600 ml of methanol are hydrogenated over 3.0 g of Pd/C (10% strength) until the starting material has disappeared (TLC). The catalyst is filtered off, and the mixture is then concentrated and dried under high vacuum. This gives 41.95 g of the title compound as a light-yellow oil. The mass spectrum shows the molecular peak MH+ at 196 Da.
Workup
- filtrationThe catalyst is filtered off
- concentrationthe mixture is then concentrated
- customdried under high vacuum
Sources & evidence
- ORD record
- ord-1c9f079b32ba46f8943c715b955e5b11
- Source dataset
- uspto-grants-2007_10
- Patent number
- US07279488B2
Reaction notes
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