2-Pyrrolidone → 1-(3-Acetylphenyl)pyrrolidin-2-one

HRID 1179527

Reaction equation

Br[C:2]1[CH:3]=[C:4]([C:8](=[O:10])[CH3:9])[CH:5]=[CH:6][CH:7]=1.[NH:11]1[CH2:15][CH2:14][CH2:13][C:12]1=[O:16]>>[C:8]([C:4]1[CH:3]=[C:2]([N:11]2[CH2:15][CH2:14][CH2:13][C:12]2=[O:16])[CH:7]=[CH:6][CH:5]=1)(=[O:10])[CH3:9]

Participants

Reactant 2

HCID 120252-Pyrrolidone

HCID 165023'-Bromoacetophenone

Product 1

HCID 71308291-(3-Acetylphenyl)pyrrolidin-2-oneYield 98%

Procedure

The title compound was prepared in 98% yield according to the general procedure for the preparation of the amides, ureas and carbamates (Method A) starting from 1-(3-bromophenyl)ethanone and 2-pyrrolidinone.

Sources & evidence

ORD record: ord-ddf3e90fcac140f49f5a47ee1588ba7f
Source dataset: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07279481B2

Linked notes

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