4-Fluorobenzoyl chloride → HCID 178522257, compound

Reaction equation

[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.ClC1C=CC(C([NH:18][C:19]2[CH:20]=[N:21][C:22]([OH:25])=[CH:23][CH:24]=2)=O)=CC=1>>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH:18][C:19]2[CH:20]=[N:21][C:22]([OH:25])=[CH:23][CH:24]=2)=[O:7])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 678794-Fluorobenzoyl chloride

HCID 178522254HCID 178522254, compound

Product 1

HCID 178522257HCID 178522257, compound

Procedure

Starting from 4-fluorobenzoyl chloride (1.59 g, 10.0 mmol) and using the procedure as described for the preparation of 4-Chloro-N-(6-hydroxy-pyridin-3-yl)-benzamide yielded the title compound, which was used without further purification.

Sources & evidence

ORD record: ord-33bf04a368194e7299d4c6e20c81a4f0
Source dataset: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07279470B2

Reaction notes

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