Carbamic chloride, N-methyl-N-phenyl- → Methyl-phenyl-carbamic Acid 4-morpholin-4-yl-phenyl Ester

HRID 1179822

Reaction equation

HRID 1179822 reaction equation
[N:1]1([C:7]2[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH3:14][N:15]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:16](Cl)=[O:17]>>[N:1]1([C:7]2[CH:8]=[CH:9][C:10]([O:13][C:16](=[O:17])[N:15]([CH3:14])[C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[CH:11][CH:12]=2)[CH2:2][CH2:3][O:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 77969Carbamic chloride, N-methyl-N-phenyl-HCID 805104-Morpholinophenol

Product 1

HCID 10171887Methyl-phenyl-carbamic Acid 4-morpholin-4-yl-phenyl Ester

Procedure

The title product was prepared from and 4-morpholin-4-yl-phenol and N-methyl-N-phenylcarbamoyl chloride. The crude product was extracted with dichloromethane from citric acid (5%). The combined organic phases were evaporated and the product crystallized from ethanol (22%, crystals). HPLC-MS: m/z=313.2 (M+1); Rt: 3.75 min.

Workup

  1. extractionThe crude product was extracted with dichloromethane from citric acid (5%)
  2. customThe combined organic phases were evaporated
  3. customthe product crystallized from ethanol (22%, crystals)

Sources & evidence

ORD record
ord-f6fd6e4b0ece44aca54192f6f8bc038b
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Linked notes

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